Effect of Vitamin D supplementation on Systemic Lupus Erythematosus / Efeito da suplementação de Vitamina D no Lúpus Eritematoso Sistêmico

Adrielly Maria Duque de Siqueira, Pâmella Grasielle Vital Dias de Souza

Abstract


Autoimmune disorders are chronic diseases characterized by loss of tolerance of the immune system, resulting in major problems in the normal functioning of the body. Among the autoimmune diseases, systemic lupus erythematosus (SLE) has received a great deal of attention given the complexity of the disease, which affects multiple organs and tissues. Among existing treatments vitamin D supplementation is being considered as a new form of treatment given the effects that vitamin D has on the immune system. Vitamin D is well known for its effects on calcium regulation and its role in metabolic processes, but research has shown that this vitamin has a pluripotent effect on many systems, including immune cells. In this context, the present study aims to relate clinical and laboratory characteristics with the presence of vitamin D supplementation in these patients. This study allowed us to draw a clinical and laboratory profile of patients with SLE positive for vitamin D supplementation. Finally, this review provided a better direction of therapy for patients diagnosed with SLE through vitamin D supplementation. as well as demonstrating the importance of adequate serum vitamin D levels for humans, for the overall functioning of the body.


Keywords


Doença Pulmonar Obstrutiva Crônica, Reabilitação, Teste de Caminhada de 6 minutos.

Full Text:

PDF

References


Araújo AD, Traverso-Yépez M. Expressões e sentidos do lúpus eritematoso sistêmico (LES). 2007; 119-127.

Furlan FLS, Lemes A, Pires CTF, Azevedo , Bernardi G, Simões S, et al. Qualidade de vida em tratamento de lúpus eritematoso sistêmico com antimaláricos. 2018; v. 16 n. 1.

Teixeira TdM, Costa CL. Papel da vitamina D no lúpus. 2012; 25(4):531-538.

Souza VAd, Bastos M, Silva NMd, Mansur , Barbosa R, souza DMKd, et al. Associação de hipovitaminose D com Lúpus Eritematoso. 2014; 36(4):430-436.

Norman W. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. 2008; 88(491S–499S).

Borba EF, Latorre C, Brenol JCT, Kayser C, Silva Ad, Zimmermann , et al. Consenso de Lúpus Eritematoso Sistêmico. Rev Bras Reumatol. 2008; v. 48, n.4( p. 196-207): p. 196-207.

Marques DL, Dantas , Fragoso T, Duarte LBP. A importância dos níveis de vitamina. 2010; 50(1):67-80.

Simioni J, Heimovski , Skare T. On lupus, vitamin D and leukopenia. 2016; 56(3)(206–211).

Galindo C, VEIGA KA. CARACTERÍSTICAS CLÍNICAS E DIAGNÓSTICASDOLÚPUS ERITEMATOSO SISTÊMICO: UMA REVISÃO. 2010; Vol 7 (4),46 -58.

Freire AM, Souto , Ciconelli R. Medidas de avaliação em lúpus eritematoso sistêmico. 2011; 51(1):70-80.

Souza AWSd, Júnior D, Araújo AP, Catelan TTT, Cruvinel dM, Andrade LEC, et al. Sistema Imunitário – Parte III O delicado equilíbrio do sistema imunológico. 2010; 50(6):665-94.

Silva ECS, Sena QMdS, Cavalcanti YVN. MECANISMOS IMUNOLÓGICOS DO LÚPUS ERITEMATOSO. 2013.

Gatti D. LÚPUS ERITEMATOSO SISTÊMICO. 2017; v. 5, n. 1.

Rodrigues D, Nascimento ECd, Carvalho LL, Silva S. DIAGNÓSTICO CLÍNICO E LABORATORIAL DO LÚPUS ERITEMATOSO SISTÊMICO. 2017; v. 4 n. 2.

Jesuz AKd, Camargo RSd. MODALIDADES DE TRATAMENTO NO LÚPUS ERITEMATOSO. 2017; 6: 23 – 44 vol.2.

Vianna R, Simões M, Inforzato HCB. LÚPUS ERITEMATOSO SISTÊMICO. 2010; 2(1): 1-3.

Costi L, Iwamoto M, Neves CdO, Caldas CAM. Mortalidade por lúpus eritematoso sistêmico no Brasil: avaliação das causas de acordo com o banco de dados de saúde do governo. 2017; vol.57 no.6.

Neves F. Dez regras práticas para a terapia com corticoides nas doenças. 2019; v. 5, n. 4.

Mezalek ZT, Bono W. Challenges for lupus management in emerging countries. 2014; 43 209-e220.

Freire , Bruscato A, Ciconelli R. Quality of life in systemic lupus erythematosus patients in Northeastern Brazil: Is health-related quality of life a predictor of survival for these patients? 2009; 34(2A):207-211.

Castro LCGd. O sistema endocrinológico vitamina D. 2011; 55/8.

Maeda SSS, Borba VZC, Camargo BR, Silva MW, Borges LC, Bandeira , et al. Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D. 2014; 58/5.

Fragoso S, Dantas T, Marques CDL, Junior LFdR, Melo JHdL, Costa AJG, et al. Níveis séricos de 25-hidroxivitamina D3 e sua associação com parâmetros clínicos e laboratoriais em pacientes com lúpus eritematoso sistêmico. 2012; vol.52.

Carrasco M, Pinto C, Aguilar JA, -Santillán P, Gallegos R, Márquez MAE, et al. Niveles séricos de vitamina D en pacientes con lupus eritematoso sistémico (LES) y su asociación con la actividad de la enfermedad: estudio longitudinal. 2016; 152:32-7.

Peracchi AB. Baixas concentrações séricas de 25-hidroxivitamina D em crianças e adolescentes com lúpus eritematoso sistêmico. 2011.

Rosa D, Galgani M, Santopaolo M, Colamatteo , Laccetti R, Matarese G. Nutritional control of immunity: Balancing the metabolic requirements with an appropriate immune function. 2015; 27, Pages 300-309.

CARVALHO J, BLANK M, KISS E, AMITAL H, SHOENFELD Y. Anti-vitamin D, vitamin D in SLE: preliminary results. 2007; 1109:550-7.

ADORINI L, Penna G. Control of autoimmune diseases by the vitamin D endocrine system. 2008; 4, pages404–412.

Kim HA, Sung JM, Jeon JY, Yoon JM, Suh CH. Vitamin D may not be a good marker of disease activity in Korean patients with systemic lupus erythematosus. 2011; 31 (9): 1189-94.

Kamen D, Oates J. A Pilot Study to Determine if Vitamin D Repletion Improves Endothelial Function in Lupus Patients. 2015; 350(4):302-7.

Lima. Avaliação da suplementação de vitamina D em pacientes com lúpus eritematoso de início juvenil: estudo clínico, randomizado, duplo-cego, controlado por placebo. 2015; 10.11606/T.5.2015.tde-14122015-120849.

Petri M, Bello , Fang , Magder. Vitamin D in systemic lupus erythematosus: modest association with disease activity and the urine protein-to-creatinine ratio. 2013; 65(7):1865-71.

Terrier , Derian , Schoindre , Chaara , Geri G, Zahr , et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. 2012; 17;14(5):R221.




DOI: https://doi.org/10.34119/bjhrv3n6-079

Refbacks

  • There are currently no refbacks.