Influência do DM2 e do controle glicêmico no prognóstico de pacientes infectados por COVID-19 / Influence of DM2 and glycemic control on the prognosis of patients infected with COVID-19

Pedro Augusto Grossi Quintão Aquino, Abner Fernandes da Silva, Alice Viana de Ávila Oliveira, Marcelo Buitrago de Andrade, Mariana Horta Nunes, Vinícius de Oliveira Viana Soares

Abstract


Objetivo: Verificar, por meio de uma revisão narrativa de literatura, a influência do DM2 no prognóstico da infecção por COVID-19, assim como o impacto do controle glicêmico nos desfechos apresentados por esses pacientes. Revisão bibliográfica: A DM2 relaciona-se com a infecção e a gravidade da SARS-CoV-2. Os sintomas apresentados pelos pacientes diabéticos infectados por SARS-CoV-2 foram muito amplo, entretanto, percebeu-se maior comorbidade nas análises laboratoriais e de imagem, além de maior mortalidade entre os pacientes diabéticos infectados pelos novo coronavírus. A literatura divergiu ao comparar o quadro clínico do pacientes diabéticos e não diabéticos infectados por COVID-19, mas convergiu ao relatar aumento da morbimortalidade. Considerações finais: A adaptação metabólica promovida pelo indivíduo diabético se mostra prejudicial no contexto do COVID-19, predispondo o paciente à infecção e ao surgimento de outras complicações, além de determinar um pior controle glicêmico e prognóstico. Tais achados destacam a necessidade de uma abordagem multidisciplinar para o gerenciamento dessa população de pacientes visando à prevenção de complicações e de formas graves da infecção.


Keywords


Infecções por coronavírus, Diabetes Mellitus tipo 2, Prognóstico

References


ALLARD, Robert et al. Diabetes and the severity of pandemic influenza A (H1N1) infection. Diabetes care, v. 33, n. 7, p. 1491-1493, 2010.

AYRES, Janelle S. A metabolic handbook for the COVID-19 pandemic. Nature Metabolism, p. 1-14, 2020.

BANERJEE, Mithu et al. Obesity and COVID-19: A Fatal Alliance. Indian Journal of Clinical Biochemistry, p. 1-8, 2020.://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351562/)

BOOTH, Christopher M. et al. Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area. Jama, v. 289, n. 21, p. 2801-2809, 2003.

BARONE, Mark Thomaz Ugliara et al. The impact of COVID-19 on people with diabetes in Brazil. Diabetes Research And Clinical Practice, [S.L.], v. 166, p. 108304, ago. 2020. Elsevier BV. http://dx.doi.org/10.1016/j.diabres.2020.108304.

CABALLERO, A. E et al. “COVID-19 in people living with diabetes: An international consensus. Journal of diabetes and its complications vol. 34,9 (2020): 107671. doi:10.1016/j.jdiacomp.2020.107671

CHAN, Kok Hoe et al. Clinical characteristics and outcome in patients with combined diabetic ketoacidosis and hyperosmolar hyperglycemic state associated with COVID-19: A retrospective, hospital-based observational case series. Diabetes research and clinical practice, p. 108279, 2020.

CHUNG, Seung Min et al. The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study. Diabetes & Metabolism Journal, v. 44, 2020.

BARONE, Mark Thomaz Ugliara et al. The impact of COVID-19 on people with diabetes in Brazil. diabetes research and clinical practice, v. 166, 2020.

CRISTELO, Cecília et al. SARS-CoV-2 and Diabetes: New Challenges for the Disease. Diabetes Research and Clinical Practice, p. 108228, 2020.

ERENER, Suheda. Diabetes, Infection Risk And Covid-19. Molecular Metabolism, p. 101044, 2020.

BANERJEE, Mithu et al. Obesity and COVID-19: A Fatal Alliance. Indian Journal of Clinical Biochemistry, p. 1-8, 2020.

GUO, Weina et al. Diabetes is a risk factor for the progression and prognosis of COVID‐19. Diabetes/metabolism research and reviews, p. e3319, 2020.

LI, Long‐quan et al. COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis. Journal of medical virology, v. 92, n. 6, p. 577-583, 2020.

MAZUCANTI, Caio Henrique; EGAN, Josephine Mary. SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done?. Immunity & Ageing, v. 17, n. 1, p. 1-11, 2020.

MANTOVANI, Alessandro et al. Diabetes as a risk factor for greater COVID-19 severity and in-hospital death: A meta-analysis of observational studies. Nutrition, Metabolism and Cardiovascular Diseases, 2020.

PAL, Rimesh; BHADADA, Sanjay K. COVID-19 and diabetes mellitus: An unholy interaction of two pandemics. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020.

PERIC, Slobodan; STULNIG, Thomas M. Diabetes and COVID-19: Disease—Management—People. Wiener Klinische Wochenschrift, p. 1, 2020.

RAOUFI, Masoomeh et al. Well-controlled vs poorly-controlled diabetes in patients with COVID-19: Are there any differences in outcomes and imaging findings?. diabetes research and clinical practice, p. 108286, 2020.

RASTAD, Hadith et al. Risk and predictors of in-hospital mortality from COVID-19 in patients with diabetes and cardiovascular disease. 2020.

VAN DEN BRAND, Judith MA; SMITS, Saskia L.; HAAGMANS, Bart L. Pathogenesis of Middle East respiratory syndrome coronavirus. The Journal of pathology, v. 235, n. 2, p. 175-184, 2015.

WANG, Sufei et al. Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study. Diabetologia, p. 1-10, 2020.

WU, Jiong et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Investigative radiology, v. 55, n. 5, p. 257, 2020.

WU, Zunyou; MCGOOGAN, Jennifer M. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. Jama, v. 323, n. 13, p. 1239-1242, 2020.

YAN, Yongli et al. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. BMJ Open Diabetes Research and Care, v. 8, n. 1, p. e001343, 2020.

YANG, J. K. et al. Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS. Diabetic medicine, v. 23, n. 6, p. 623-628, 2006.

ZHENG, Yan; LEY, Sylvia H.; HU, Frank B. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews Endocrinology, v. 14, n. 2, p. 88, 2018.

ZHENG, Ying; WANG, Ling; BEN, Suqin. Meta‐analysis of chest CT features of patients with COVID‐19 pneumonia. Journal of Medical Virology, 2020.




DOI: https://doi.org/10.34119/bjhrv3n4-363

Refbacks

  • There are currently no refbacks.