Comparação da eficácia dos medicamentos para indução de ovulação em mulheres com Síndrome do Ovário Policístico resistentes ao citrato de clomifeno / Comparison of the efficacy of ovulation induction drugs in women with polycystic ovary syndrome resistant to clomiphene citrate

Natália Bianca Vales Bhering, Maria Luiza Andrade Aquino, Aline Kozuch, Cecília Andrade Silva, Iara Teixeira da Silva, Isabela Maria Arantes, Letícia Natsumi Koga, Maria Carmem Bicalho Moreira, Maria Clara Mota de Oliveira, Victoria Luiza Pires

Abstract


Introdução: A Síndrome dos Ovários Policísticos (SOP), atual Síndrome da Anovulação Crônica Hiperandrogênica, é a causa mais comum de infertilidade anovulatória. O citrato de clomifeno (CC) é considerado a primeira linha de tratamento medicamentoso, entretanto, até 20% das mulheres podem ser resistentes a essa terapia. Objetivo: Comparar a eficácia dos medicamentos indutores da ovulação em mulheres portadoras de SOP resistentes ao CC. Metodologia: Trata-se de uma revisão narrativa de artigos do ano 2015 a 2020 realizada nas bases de dados: MEDLINE, LILACS, SCiELO e BVS. Resultados: Os artigos, contemplavam publicações de autores e periódicos de diferentes nacionalidades. A maioria dos artigos abrangeram os anos de 2019 (três) e 2017 (três) sendo todos publicados nos últimos 5 anos. Discussão: A fisiopatologia da infertilidade anovulatória na SOP é composta por alterações hormonais como FSH diminuído, aumento de LH, resistência insulínica e hiperinsulinemia. Essa desregulação hormonal é responsável pela infertilidade, pois, promove o desenvolvimento anormal do folículo. Letrozol, Metformina, Inositol, Gonadotrofinas e suas combinações compõem as principais opções medicamentosas para pacientes com resistência ao CC. Conclusão: O uso do Letrozol isolado ou combinado com Gonadotrofinas ou Metformina apresentou os melhores resultados nas taxas de gravidez e ovulação, além do melhor custo benefício.


Keywords


Síndrome dos Ovários Policísticos, infertilidade, terapia medicamentosa.

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DOI: https://doi.org/10.34119/bjhrv3n4-340

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