Staphylococcus aureus resistentes aos β-lactâmicos em mastites de gado leiteiro: uma meta-análise / Staphylococcus aureus resistant to β-lactam antibiotics in mastitis dairy herds: a meta-analysis

Caroline Pissetti, Ana Paula Serafini Poeta Silva, Waldemir Santiago Neto, Eduardo de Freitas Costa

Resumo


Staphylococcus aureus está comumente relacionada em casos de mastite em rebanhos leiteiros, sendo considerada a principal causa do uso de antimicrobianos na prática leiteira, sendo a resistência a antimicrobianos é uma realidade na prática veterinária. De qualquer forma o uso de antimicrobianos em rebanhos leiteiros ainda se faz necessário sendo então importante constante atualização sobre o conhecimento do nível de resistência antimicrobiana para gestão tanto de saúde animal quanto pública. Por esse motivo, o objetivo deste estudo é estimar a prevalência de resistência antimicrobiana aos antimicrobianos representantes do grupo β-lactâmicos utilizados em rebanhos leiteiros com mastite. Desta forma, uma revisão sistemática e meta-análise foi realizada. Foram encontrados 219 artigos, seis foram recuperados pela leitura das referências. Dezenove artigos foram aprovados para meta-análise. A prevalência de resistência foi estimada em 40% para penicilina, 29% para ampicilina e 0,1% para cefalotina e oxacilina. Existe uma diferença significativa entre a prevalência de resistência entre as diferentes classes de antimicrobianos (valor p <0,05). Para penicilina e ampicilina, foram encontrados grandes valores de heterogeneidade (valor p <0,05) entre os estudos (I² acima de 90%), mas para oxacilina e cefalotina foram encontrados os menores valores entre os estudos (I² = 80% e 56%, respectivamente). Este estudo estimula a discussão das fontes de heterogeneidade e outros estudos, como com outros subgrupos, com análises de meta-regressão precisam ser conduzidas para identificar essas características.


Palavras-chave


β-lactamases, mastite estafilocócica, meta-regressão, resistência antimicrobiana, revisão sistemática.

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Referências


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DOI: https://doi.org/10.34188/bjaerv4n1-064

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