Atividades antioxidante e inibitória da acetil colinesterase do extrato das folhas de Hymenaea rubriflora / Antioxidant and acetylcholinesterase inhbition activity from Hymenaea rubriflora Ducke (Fabaceae) leaf extract

Paulo Henrique Oliveira de Miranda, Graziela Claudia da Silva, Luciclaudio Cassimiro de Amorim, João Victor de Oliveira Alves, Caio Rodrigo Dias de Assis, Michelle Melgarejo da Rosa, Maria Tereza dos Santos Correia, Márcia Vanusa da Silva


Hymenaea rubriflora is an endemic and edible plant from tropical weather, especially present in Brazilian flora and have been reported as medicinal plant in ethnobotanical studies. There has been less previous evidence regarding its biological application, therefore, to overcome this problem the present work aimed to evaluate whether the metabolites of Hymenaea rubriflora host antioxidant and anti- acetylcholinesterase (AChE) activity. To investigate these activities a whole range of different approaches as phytochemical screening, lipidic peroxidation, DPPH scavenging and total antioxidant capacity, and acetylcholinesterase inhibition assay were used. The analysis found evidence for the presence of different secondary metabolites, among them: phenolic compounds (at 286.02 ± 1.75 GAE/mg.DW concentration), flavonoids ( at 23.19 ± 2.38 QE/mg.DW concentration), known as natural antioxidants and highlighted its effectiveness as AChE inhibitor, being able to inhibit AChE activity in 96% on 10 mg/mL. In this study we provide insights of H. rubriflora extract as an alternative antioxidant and AchE inhibitor agent, relevant to the context of neurological disorders and cognitive processes.



Hymenaea rubriflora, antioxidant activity, Acetylcholinesterase inhibitor

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