Berries and leukemia: a systematic review of experimental studies and the in vitro effect of ellagic acid on chronic myeloid leukemia cells / Frutas vermelhas e leucemia: uma revisão sistemática de estudos experimentais e o efeito in vitro do ácido elágico sobre células de leucemia mieloide crônica

Juliana Silva Garcia Borges, Julia Quarti Cardoso, Ana Luisa Kremer Faller, Eliane Fialho

Abstract


Diet is directly involved in cancer etiology, influencing positively or negatively. The aim of this study was to conduct a systematic review on the effect of berries on leukemia, identifying the main bioactive compounds involved in biochemical and molecular mechanisms through which they act and also to test the in vitro effect of ellagic acid, one of the phytochemicals found in berries, on leukemia cells. The work was subdivided into two parts: the first consisted of analysis of abstracts in Pubmed / Medline databases using MeSH (Medical Subject Headings) terms, synonyms, related and free terms, such as: leukemia, berries, anthocyanins, ellagic acid and flavonoids resulting in 274 articles. After abstract analysis, based on the eligibility criteria, this number was reduced to 21 articles. The second part was the in vitro investigation of the effect of ellagic acid by the MTT reduction in chronic myeloid leukemia cell lines (CML) resistant or not to chemotherapeutic agents. In vitro, in vivo and ex vivo studies associated the bioactive compounds present in berries with anticancer effect, acting mainly by induction of metabolic enzymes, modulation of gene expression and cell proliferation, chemotherapic resistance, free radical scavenging and induction of apoptosis. The present work also highlights the induction of collateral sensitivity by ellagic acid, since this compound was able to preferentially act on chemotherapeutic resistant cells. However, it is emphasized that animal models and clinical trials are for establishing the main mechanisms of action and possible dosages of berries intake daily or by dietary supplementation that could contribute to leukemia's treatment.

  


Keywords


leukemia, berries, anthocyanins, ellagic acid and flavonoids.

References


ASOU, H. et al. Resveratrol, a natural product derived from grapes, is a new inducer of differentiation in human myeloid leukemias. Int. J. Hemat., v.75(5), p.528-533, 2002.

BARAN, Y. et al. Upregulation of multidrug resistance genes in doxorubicin resistant human acute leukemia cells and myelogeneous reversal of the resistance. Hematology, v. 12(6), p.511-517, 2007.

DAFLON-YUNES, N. et al. Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms. Molecular and Cellular Biochemistry, v.383, p.123-135, 2013.

DAHLAWI, H. et al. Polyphenols are responsible for the proapoptotic properties of promegranate juice on leukemia cell lines. Food Sci. Nut., v.1(2), p.196-208, 2013.

ESTEY, E. & DOHNER, H. Acute myeloid leukemia. Lancet, v.368, p.1894-1907, 2006.

FENG, R. et al. Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress. J. Biol. Chem., v.282 (18), p.13468–13476, 2007.

FERLAY, J. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer, v.136, p.E359–E386, 2015.

FIMOGNARI, C. et al. Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-b-glucopyranoside. Biochem Pharmacol., v.67(11), p.2047-2056, 2004.

FLORES, E. et al. P63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature, v.416, p.560-564, 2002.

GARCIA-ALONSO, F. J. et al. Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert- butylhydroperoxide in U937 cells: the role of iron chelation. J. Nut. Biochem., v.18, p.457–466, 2007.

GE, J. et al. Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK. Biomed. Environ. Sci., v.26(11), p.902-911, 2013.

GUPTA, S. C. et al. Chemosensitization of tumors by resveratrol. Ann. N Y Acad. Sci., v.1215, p.150-160, 2011.

GUTTERIDGE, J. M. & HALLIWELL, B. Free radicals and antioxidants in the year 2000: a historical look to the future. Ann. N. Y. Acad. Sci, v.899, p.136-147, 2000.

HAGIWARA, A. et al. Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells. Int. J. Hematol., v.92, p.136–43, 2010.

HOLLSTEIN, M. et al. P53 mutations in human cancers. Science, v.5(253), p.49-53, 2015.

KATSUBE, N. et al. Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J. Agric. Food Chem., v.51, p.68-75, 2003.

KATSUZAKI, H. et al. Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. Oncol Rep., v.10(2), p.297-300, 2003.

KOEFFLER, H. P. & GOLDE, D. W. Human myeloid leukemia cell lines: a review. Blood., v.56, p.344-350, 1980.

KWEON, S. H. et al. Resveratrol-mediated reversal of doxorubicin resistance in acute myeloid leukemia cells via downregulation of MRP1 expression. Biochem. Biophys. Res. Commum., v.395, p.104–110, 2010.

MAIURI, M. C. et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell. Biol., v.8, p.741-752, 2007.

MERTENS-TALCOTT, S. U. et al. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J. Nutr., v.133, p.2669–2674, 2003.

MERTENS-TALCOTT, S. U. & PERCIVAL, S. S. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Letters, v.218, p.141–151, 2005.

NILE, S. H. & PARK, S. W. Edible berries: Bioactive components and their effect on human health. Nutrition, v.30, p.134-144, 2014.

NUNEZ, G. et al. Caspases: the proteases of the apoptotic pathway. Oncogene, v.17(25), p.3237-3245, 1998.

RUMJANEK V. M. et al. Multidrug resistance in tumour cells: characterization of the multidrug resistant cell line K562-Lucena 1. Anais da Academia Brasileira de Ciências, v.73, p.57-69, 2001.

SAEDI, T. A. et al. Berberis vulgaris fruit crude extract as a novel anti-leukaemic agent. Journal of Biological Regulators and Homeostatic Agents, v.2(2), p.395-399, 2015.

SEERAM, N. P. Berry fruits: Compositional elements biochemical activities and the impact of their intake on human health, performance, and disease. J. Agric. Food Chem., v.56, p.627-629, 2008.

SHARIF, T. et al. Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redoxsensitive up-regulation of p73 and down-regulation of UHRF1. Eur. J. of Cancer, v.46, p.983-994, 2010.

SHARIF, T. et al., Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells. Plos One, v.7(3), p.1-11, 2012.

SKUPIEN, K. et al. In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells. Cancer Letters, v.236, p.282–291, 2006.

STONER, G. D. & SEERAM, N. P. Berrys and cancer prevention. Springer Science Bussiness Media, LLC 2011.

STRANO, S. et al. Physical and functional interaction between p53 mutants and different isoforms of p73. J Biol Chem., v.275(29), p.503-12, 2000.

STRATTON, M. R. Exploring the genomes of cancer cells: progress and promise. Science, v.25(6024), p.1553-1558, 2011.

SZYMANOWSKA, U. et al. Antioxidant, anti-Inflammatory, and postulated cytotoxic activity of phenolic and anthocyanin-rich fractions from polana raspberry (Rubus idaeus L.) fruit and juice—In vitro study. Molecules, v.23(1812), p.1-17, 2018.

WANG, M. et al. Monocytic differentiation of K562 cells induced by proanthocyanidins from grape seeds. Arch Pharm Res., v.35(1), p.129-135, 2012.

WANG, Y. S. et al. Antioxidant activity in lingonberries (Vaccinium vitis-idaea L.) and its inhibitory effect on activator protein-1, nuclear factor-KB, and mitogen-activated protein kinases activation. J. Agric. Food Chem., v.53, p.3156−3166, 2005.

WANG, S. Y. et al. Antioxidant activity of Vaccinium stamineum: exhibition of anticancer capability in human lung and leukemia cells. Planta Med., v.73(5), p.451-60, 2007. Epub 2007 Mar 29.

WHITE, E. & DIPAOLA, R. S. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res., v.15, p.5308-5316, 2009.

WILMS, L. C. et al. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis, v.28(8), p.1800–1806, 2007.

YANG, Z. J. et al. The role of autophagy in cancer: therapeutic implications. Mol. Cancer Ther., v.10, p.1533-1541, 2011.

ZHAO, Y. Berry fruit value-added products for health promotion. Boca Raton, FL: CRC Press 2007; 448p.




DOI: https://doi.org/10.34119/bjhrv3n3-042

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